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Independent GLP-1 cost & value lab · 2026

Run the numbers before you pick a GLP-1 provider.

We model the real monthly and annual cost of every major GLP-1 telehealth program, then rank them on The Cost-Efficiency Index — value for money, not the lowest teaser rate. 529 providers on the bench.

See the value leaderboard All cost calculators
529
Providers modeled
6
Index factors
0
Score points bought

Monthly Cost Calculator

Live model
Molecule

Modeled / month

$99

Modeled / year

$1,188

As CoreAge Rx publishes it: $99/mo

Lowest disclosed semaglutide in our ranking: Collective at $59/mo — but check the full Cost-Efficiency Index before you decide on price alone.

Start with CoreAge Rx Read the review →

Modeled from each provider's published monthly price at last review. Excludes shipping, labs, and consult fees where not bundled. Prices change — confirm on the provider's site. Not medical advice.

#1 by value — top of the Cost-Efficiency Index

CoreAge Rx

Best value in the ranking: both molecules at one flat, all-50 price with no teaser step-ups — the lowest true cost of ownership, not the lowest teaser.

Specifically want FDA-approved brand tirzepatide instead of a compounded copy? See what Zepbound actually costs before you compare compounded prices.

The value leaderboard

Best-value GLP-1 providers, measured & ranked

Scored on six factors: normalized cost/month · price transparency · nationwide access · formulation options · clinical oversight · contract flexibility. Assume any provider we list may compensate us — see our disclosure. It never changes a Cost-Efficiency Index. In a hurry? Jump to the cheapest GLP-1 providers worth using, or if you already know your molecule, see the cheapest tirzepatide over a year.

#1 by value
#1Grade A

CoreAge Rx

Best value in the ranking: both molecules at one flat, all-50 price with no teaser step-ups — the lowest true cost of ownership, not the lowest teaser.

Semaglutide
$99/mo
Tirzepatide
$149/mo
Coverage
All 50 states
Brand-name
Compounded only
  • Flat all-in monthly price — no intro rate that silently triples after month one, so the modeled annual cost is the real cost
  • Both compounded semaglutide and tirzepatide on one account at published prices
  • Available in all 50 states — no coverage gamble
  • Not the rock-bottom sticker price — 30 of the 371 priced semaglutide programs we track list a cheaper figure, though most attach a term or a step-up that CoreAge does not
  • No FDA-approved brand-name option (compounded only)
  • Does not yet publicly name its 503A/B pharmacy partner
Visit CoreAge Rx Read the full review →
#2Grade B+

Found

A real insurance-billing pathway on both molecules — but the widely-quoted $99/mo headline requires an insurance plan AND a full year prepaid upfront; the true no-commitment rate is $199-289/mo.

Semaglutide
$199/mo (insurance-linked)
Tirzepatide
$199/mo (insurance-linked)
Coverage
All 50 states
Brand-name
Compounded only
  • Genuine insurance-billing pathway, unlike most cash-only compounded competitors — most members reportedly pay under $30/visit
  • Nationwide
  • Strong behavior-change program adds value
  • The advertised '$99/mo' headline requires BOTH an insurance-linked plan AND a 12-month prepay at once — the real month-to-month rate is $199/mo (insured) or $289/mo (cash-pay), 2-3x the headline
  • Coaching subscription can't be unbundled, which reduces contract flexibility
  • Compounded only
Visit Found Read the full review →
#4Grade B+

ShedRx (Shed)

The widest set of formats in the ranking — injection, drops, lozenges and a daily oral pill, plus a real brand Zepbound route — though its cheapest advertised rates need a year-long commitment.

Semaglutide
$199/mo ($159 on a 12-month plan)
Tirzepatide
$299/mo ($239 on a 12-month plan)
Coverage
All 50 states
Brand-name
Yes
  • Four routes to a GLP-1 — injection, liquid drops, lozenges and a daily oral pill
  • Brand Zepbound and Wegovy available alongside the compounded line
  • Available in all 50 states, with health coaching included and a published 120-day weight-loss guarantee
  • The advertised "as low as" prices ($159 semaglutide, $239 tirzepatide) require a TWELVE-MONTH commitment — month-to-month is $199 and $299
  • Compounded medication is not FDA-approved the way brand Ozempic, Wegovy, or Zepbound are
  • The dispensing compounding pharmacy is not publicly named
Visit ShedRx (Shed) Read the full review →

Ranks 4–10

#5

Strut Health

B+ · 87Partner

$99/month sublingual semaglutide — among the lowest entry costs we track — from one of the very few programs selling the same molecule as a lozenge or an injection at a single price.

Sema From $99/mo sublingual, $149/mo injectable
Tirz From $199/mo either route
Visit Review →

Regulatory note: FDA warning letter issued to Strut Health, LLC dba Strut, February 2026.

#6

Breeze Meds

B · 86Partner

The most transparent operator in our partner tier — all-50 compounded GLP-1 with NPI-verifiable named physicians, named pharmacies and LegitScript backing, so you can actually audit who's behind the script.

Sema $199/mo
Tirz $399/mo on the product grid; the post-intake screen shows $299 — Breeze publishes both
Visit Review →
#7

Sesame Care

B · 86Partner

The widest real brand-name GLP-1 access in the ranking — a LegitScript- and BBB-recognized national marketplace running since 2018 that dispenses FDA-approved Wegovy, Zepbound, Ozempic, Mounjaro and Rybelsus, not compounded copies.

Sema $149/mo medication + $59/mo care subscription (that rate needs a 12-month commitment)
Tirz Brand (Zepbound)
Visit Review →
#9

Sprout Health

B · 85Partner

Low-friction and well-priced — $149 compounded semaglutide and $199 tirzepatide from a LegitScript-certified operator, with a brand Wegovy/Zepbound path if you want to step up.

Sema $149/mo
Tirz $199/mo
Visit Review →

Regulatory note: FDA warning letter issued to Sprout Health Partners LLC dba Sprout Health, September 2025.

#23

Care Bare Rx

B− · 80Partner

A LegitScript-certified, HIPAA-compliant multi-service platform bundling weight loss with hair, TRT, sexual health and NAD+ — both oral (Rybelsus, oral tirzepatide) and injectable compounded routes, real brand Ozempic from ~$705/mo, and coverage across all 50 states plus Puerto Rico, but the 3-month plan is a real trap: it costs more per month than either month-to-month or the 6-month plan.

Sema $199/mo month-to-month ($185/mo only on a 12-month prepay; the 3-month tier is dearer at $249/mo)
Tirz $299/mo month-to-month ($293/mo only on a 12-month prepay; the 3-month tier is dearer at $356/mo)
Visit Review →
#30

Trimi Health

C · 78Partner

Publishes a complete four-rung price ladder for both molecules and advertises the deepest rung: the $99 semaglutide and $125 tirzepatide headlines are annual-prepay rates, while month-to-month is $175 and $235.

Sema $175/mo month-to-month ($99/mo only on a 12-month prepay)
Tirz $235/mo month-to-month ($125/mo only on a 12-month prepay)
Visit Review →
#39

Enhance MD

C · 75Partner

The clearest tiered price ladder in this ranking — separate published lines for semaglutide, tirzepatide, a microdose tier and a sema+tirz combo — with lab work built into every tier.

Sema $212/mo (first month $112)
Tirz $280/mo (first month $180)
Visit Review →

That is the top 10 of the 529 providers we score, in ranking order. The rest are scored on the same six factors — every provider is indexed here, or put two head-to-head on the comparison bench.

Pricing, states and verification facts reflect each provider's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on the provider's site. Not medical advice.

Monthly Cost Calculator

Model the monthly + annual cost of any provider by molecule.

Savings Estimator

Compare compounded pricing against brand-name list prices.

Cost-per-Month Table

Sort every provider by price and cross-check the Index.

Value, not teaser price

We normalize cost against what you actually get — both molecules, flat pricing, real access — so the cheapest sticker doesn't automatically win.

Honest low scores

Opaque pricing and coverage gaps drag scores down, and we say exactly why. A leaderboard that flatters everyone is useless.

Funded openly

Assume any provider we list may compensate us — we may earn a commission if you sign up through our links, at no extra cost to you. The Cost-Efficiency Index is printed unmodified.

Read the full Cost-Efficiency Index methodology →